Unit 2: Acids, Bases, Buffers & Dental Products

February 14, 2026

Semester 1
BP104T

Introduction to Acids, Bases, Buffers & Dental Products

Unit 2 covers the chemistry of body fluids and dental care. You will learn about ‘Buffers’ which maintain the pH of pharmaceutical formulations and body fluids. The section on ‘Electrolytes’ covers life-saving fluids like ORS and Calcium Gluconate. Finally, ‘Dental Products’ explains the science behind your toothpaste—how Fluorides prevent cavities and how Desensitizing agents work.

Syllabus & Topics

  • 1Acids, Bases and Buffers: Buffer equations (Henderson-Hasselbalch)
  • 2Buffer Capacity and factors affecting it
  • 3Buffered Isotonic Solutions: Measurement of tonicity, Calculations (Freezing point depression, NaCl equivalent)
  • 4Major Electrolytes: Intra and Extracellular ions
  • 5Replacement Therapy: NaCl, KCl, Calcium Gluconate, ORS
  • 6Physiological Acid-Base Balance
  • 7Dental Products: Dentifrices, Role of Fluoride, Desensitizing agents
  • 8Compounds: Calcium carbonate, Sodium fluoride, Zinc eugenol cement

Learning Objectives

Derive the Henderson-Hasselbalch equation.
Calculate the amount of adjusting substance needed for isotonicity.
Explain the composition and use of Oral Rehydration Salts (ORS).
Check the role of Fluoride in preventing dental caries.
List the ingredients used in Dentifrices.

Frequently Asked Questions (FAQs)

Q1. What is Buffer Capacity?

Buffer capacity is a measure of the ability of a buffer solution to resist changes in pH when small amounts of acid or alkali are added. It is maximum when pH = pKa.

Q2. Why is Fluoride used in dental products?

Fluoride ions replace hydroxyl ions in hydroxyapatite of tooth enamel to form fluorapatite, which is harder and more resistant to acid attack, thereby helping to prevent dental caries.

Q3. What are Desensitizing Agents?

Desensitizing agents (such as strontium chloride and zinc chloride) are used in toothpastes to reduce tooth sensitivity to hot or cold stimuli by blocking dentinal tubules.

Q4. What is ORS?

Oral Rehydration Salt (ORS) is a mixture of electrolytes (NaCl, KCl, sodium citrate) and dextrose, used to treat dehydration caused by diarrhea. It helps restore fluid and electrolyte balance in the body.

Q5. Calculate the isotonicity of 1% Boric Acid.

Using the freezing point depression method:

  • Freezing point of 1% w/v boric acid = –0.288°C

  • Freezing point of blood plasma = –0.52°C

Since –0.288°C > –0.52°C, the solution is hypotonic.